Structure via PubChem · Public domain (PubChem)
pinacidil
Sign in to saveAlso known as Pindac®, pinacidil anhydrous
Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles. It reduces blood pressure and peripheral resistance and produces fluid retention.
In the Vinony graph
Vinony's link graph records 327 inbound references to pinacidil, and connects out to valproic acid, (RS)-baclofen and voltage-gated sodium channel.
It sits within the topics 4-Pyridyl compounds, Chemical articles with multiple CAS registry numbers and Chemical articles with multiple compound IDs.
Vinony links it to 10 Wikipedia language editions.
Chemical data
- Formula
- C13H19N5
- Molecular weight
- 245.32 g/mol
- IUPAC name
- 1-cyano-2-(3,3-dimethylbutan-2-yl)-3-pyridin-4-ylguanidine
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1989
- Admin. routes
- oral
via ChEMBL · EBI
Research
1,548 papers- Pinacidil ameliorates cardiac microvascular ischemia-reperfusion injury by inhibiting chaperone-mediated autophagy of calreticulin.Basic research in cardiology · 2024
- Pinacidil. Preclinical investigations.Drugs · 1988
- Pinacidil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the treatment of hypertension.Drugs · 1990
- Repositioning pinacidil and its anticonvulsant and anxiolytic properties in murine models.Scientific reports · 2024
- Cromakalim, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle.General pharmacology · 1989
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 245.164046
- Has use
- medication
Show 5 more facts
- canonical SMILES
- CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1
- isomeric SMILES
- CC(N/C(=N\C#N)/NC1=CC=NC=C1)C(C)(C)C
- Commons category
- Pinacidil
- defined daily dose
- 50
- chemical formula
- C₁₃H₁₉N₅
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- References
- External links
Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles. It reduces blood pressure and peripheral resistance and produces fluid retention.
Pinacidil has been associated with development of hypertrichosis in 2 to 13% of patients.
Excerpted from Wikipedia’s “pinacidil” article, available under the CC BY-SA 4.0 licence.