Structure via PubChem · Public domain (PubChem)
pindolol
Sign in to saveAlso known as VKN646, betapindol, LB-46, Visken®, 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]propan-2-ol, 4-(2-hydroxy-3-isopropylaminopropoxy)-indole, 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)-propan-2-ol
Pindolol, sold under the brand name Visken among others, is a non-selective beta blocker which is used in the treatment of hypertension. It is also an antagonist of the serotonin 5-HT1A receptor, preferentially blocking inhibitory 5-HT1A autoreceptors, and has been researched as an add-on therapy to various antidepressants, such as clomipramine and the selective serotonin reuptake inhibitors (SSRIs), in the treatment of depression and obsessive–compulsive disorder (OCD).
Key facts
- Drug.Verifiedfields
- verified
- Drug.verifiedrevid
- 408558126
- Drug.image
- Pindolol skeletal.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula of pindolol
- Drug.width
- 250px
- Drug.image2
- Pindolol-3D-spacefill.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Space-filling model of the pindolol molecule
- Drug.width2
- 225px
- Drug.tradename
- Visken, others
- Drug.MedlinePlus
- a684032
- Drug.pregnancy_AU
- C
- Drug.pregnancy_US
- B
- Drug.legal_status
- Rx-only
- Drug.routes_of_administration
- By mouth, intravenous
- Drug.class
- Beta blocker; β-Adrenergic receptor antagonist; Non-selective β1- and β2-adrenergic receptor receptor antagonist
- Drug.ATC_prefix
- C07
via Wikipedia infobox
Chemical data
- Formula
- C14H20N2O2
- Molecular weight
- 248.32 g/mol
- IUPAC name
- 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
- SMILES
- CC(C)NCC(COC1=CC=CC2=C1C=CN2)O
- InChIKey
- JZQKKSLKJUAGIC-UHFFFAOYSA-N
- XLogP
- 1.8
- Polar surface area
- 57.3 Ų
- H-bond donors
- 3
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
4,834 papers- Pindolol augmentation of antidepressant response.Current drug targets · 2006
- Pindolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects.Pharmacotherapy · 1982
- Pindolol augmentation of antidepressants: a review and rationale.The Australian and New Zealand journal of psychiatry · 2000
- Pindolol augmentation of selective serotonin reuptake inhibitors: accounting for the variability of results of placebo-controlled double-blind studies in patients with major depression.Human psychopharmacology · 2005
- Clinical pharmacology of pindolol.American heart journal · 1982
via PubMed
Wikidata facts
- Mass
- 248.152
Show 6 more facts
- MCN code
- 2933.99.13
- chemical formula
- C₁₄H₂₀N₂O₂
- canonical SMILES
- CC(C)NCC(COC1=CC=CC2=C1C=CN2)O
- World Health Organisation international non-proprietary name
- pindolol
- Commons category
- Pindolol
- defined daily dose
- 15
Sources (6)
via Wikidata · CC0
~7 min read
Article
11 sectionsContents
- Medical uses
- Contraindications
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- Research
- Depression
- See also
- References
Pindolol, sold under the brand name Visken among others, is a non-selective beta blocker which is used in the treatment of hypertension. It is also an antagonist of the serotonin 5-HT1A receptor, preferentially blocking inhibitory 5-HT1A autoreceptors, and has been researched as an add-on therapy to various antidepressants, such as clomipramine and the selective serotonin reuptake inhibitors (SSRIs), in the treatment of depression and obsessive–compulsive disorder (OCD).
==Medical uses== Pindolol is used for hypertension in the United States, Canada, and Europe, and also for angina pectoris outside the United States. When used alone for hypertension, pindolol can significantly lower blood pressure and heart rate, but the evidence base for its use is weak as the number of subjects in published studies is small. In some countries, pindolol is also used for arrhythmias and prophylaxis of acute stress reactions. It has been used to treat anxiety as well.