pindolol
Also known as VKN646, betapindol, LB-46, Visken®, 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]propan-2-ol, 4-(2-hydroxy-3-isopropylaminopropoxy)-indole, 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)-propan-2-ol
Pindolol, sold under the brand name Visken among others, is a non-selective beta blocker which is used in the treatment of hypertension. It is also an antagonist of the serotonin 5-HT1A receptor, preferentially blocking inhibitory 5-HT1A autoreceptors, and has been researched as an add-on therapy to various antidepressants, such as clomipramine and the selective serotonin reuptake inhibitors (SSRIs), in the treatment of depression and obsessive–compulsive disorder (OCD).
Key facts
- Drug.Verifiedfields
- verified
- Drug.verifiedrevid
- 408558126
- Drug.image
- Pindolol skeletal.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula of pindolol
- Drug.width
- 250px
- Drug.image2
- Pindolol-3D-spacefill.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Space-filling model of the pindolol molecule
- Drug.width2
- 225px
- Drug.tradename
- Visken, others
- Drug.MedlinePlus
- a684032
- Drug.pregnancy_AU
Article
11 sectionsContents
- Medical uses
- Contraindications
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- Research
- Depression
- See also
- References
Pindolol, sold under the brand name Visken among others, is a non-selective beta blocker which is used in the treatment of hypertension. It is also an antagonist of the serotonin 5-HT1A receptor, preferentially blocking inhibitory 5-HT1A autoreceptors, and has been researched as an add-on therapy to various antidepressants, such as clomipramine and the selective serotonin reuptake inhibitors (SSRIs), in the treatment of depression and obsessive–compulsive disorder (OCD).
==Medical uses== Pindolol is used for hypertension in the United States, Canada, and Europe, and also for angina pectoris outside the United States. When used alone for hypertension, pindolol can significantly lower blood pressure and heart rate, but the evidence base for its use is weak as the number of subjects in published studies is small. In some countries, pindolol is also used for arrhythmias and prophylaxis of acute stress reactions. It has been used to treat anxiety as well.