Structure via PubChem · Public domain (PubChem)
arotinolol
Sign in to saveArotinolol (INN, marketed under the tradename Almarl) is a medication in the class of mixed alpha/beta blockers. It also acts as a β3 receptor agonist. A 1979 publication suggests arotinolol as having first been described in the scientific literature by Sumitomo Chemical as "β-adrenergic blocking, antiarrhythmic compound S-596".
In the Vinony graph
Vinony's link graph records 569 inbound references to arotinolol, and connects out to propranolol, adrenergic receptor and atenolol.
Vinony files it under Alpha-1 blockers, Beta3-adrenergic agonists and Beta blockers.
Vinony links it to 8 Wikipedia language editions.
Chemical data
- Formula
- C15H21N3O2S3
- Molecular weight
- 371.5 g/mol
- IUPAC name
- 5-[2-[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide
- SMILES
- CC(C)(C)NCC(CSC1=NC(=CS1)C2=CC=C(S2)C(=O)N)O
- InChIKey
- BHIAIPWSVYSKJS-UHFFFAOYSA-N
- XLogP
- 2.3
- Polar surface area
- 170 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
101 papers- Effect of arotinolol on chronic heart failure: A systematic review and meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2022
- Treatment of essential tremor with arotinolol.Neurology · 1988
- Enantiospecific determination of arotinolol in rat plasma by LC-MS/MS: application to a stereoselective pharmacokinetic study.Journal of pharmaceutical and biomedical analysis · 2015
- Arotinolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes.Canadian journal of physiology and pharmacology · 2001
- Adrenoceptor blocking effects of arotinolol, a new combined alpha- and beta-adrenoceptor blocking agent.Archives internationales de pharmacodynamie et de therapie · 1984
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 371.07959
- Has use
- medication
Show 3 more facts
- chemical formula
- C₁₅H₂₁N₃O₂S₃
- canonical SMILES
- CC(C)(C)NCC(CSC1=NC(=CS1)C2=CC=C(S2)C(=O)N)O
- subject has role
- beta blocker
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- Medical uses
- References
- External links
{{Drugbox | Verifiedfields = changed | verifiedrevid = 457153102 | IUPAC_name = (RS)-5-(2-{[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl}- 1,3-thiazol-4-yl)thiophene-2-carboxamide | image = Arotinolol.svg | image_class = skin-invert-image | width = 275px
| tradename = Almarl | Drugs.com = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = Rx-only | routes_of_administration = Oral (tablets)
Excerpted from Wikipedia’s “arotinolol” article, available under the CC BY-SA 4.0 licence.