POLA1
Sign in to saveAlso known as NSX, POLA, p180, Polymerase (DNA directed), alpha 1, polymerase (DNA) alpha 1, catalytic subunit, DNA polymerase alpha 1, catalytic subunit, VEODS
protein-coding gene in the species Homo sapiens
Gene data
POLA1- Name
- DNA polymerase alpha 1, catalytic subunit
- Type
- protein-coding
- Chromosome
- X
- Position
- 24,693,864–24,996,986 (+)
- Aliases
- NSX, PDR, POLA, VEODS, p180
- Ensembl
- ENSG00000101868
- RefSeq RNA
- NM_001330360.2, NM_001378303.1, NM_001440806.1, NM_016937.4, NR_165482.1
- RefSeq protein
- NP_001317289.1, NP_001365232.1, NP_001427735.1, NP_058633.2, XP_011543842.1
This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010].
Gene Ontology
Biological process
Molecular function
Pathways
DNA replication - Homo sapiens (human)Inhibition of replication initiation of damaged DNA by RB1/E2F1E2F mediated regulation of DNA replicationTelomere MaintenanceCell CycleDiseasePolymerase switching on the C-strand of the telomereTelomere C-strand (Lagging Strand) SynthesisTelomere C-strand synthesis initiationExtension of Telomeres
via MyGene.info
Gene · Ensembl
DNA polymerase alpha 1, catalytic subunit
- Symbol
- POLA1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:24,693,864-24,996,986
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI