Structure via PubChem · Public domain (PubChem)
In the Vinony graph
Within Vinony's link graph, polythiazide is referenced by 79 other articles, and connects out to collecting duct system, Na-K-Cl cotransporter and medication.
Vinony files it under Benzothiadiazines, Carbonic anhydrase inhibitors and Chemical pages without DrugBank identifier.
Its subject is documented across 9 Wikipedia language editions.
Chemical data
- Formula
- C11H13ClF3N3O4S3
- Molecular weight
- 439.9 g/mol
- IUPAC name
- 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide
- SMILES
- CN1C(NC2=CC(=C(C=C2S1(=O)=O)S(=O)(=O)N)Cl)CSCC(F)(F)F
- InChIKey
- CYLWJCABXYDINA-UHFFFAOYSA-N
- XLogP
- 2.6
- Polar surface area
- 152 Ų
- H-bond donors
- 2
- H-bond acceptors
- 11
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1961
- Admin. routes
- oral
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
302 papers- Polythiazide.2006
- Diuretics.2012
- Kinetics of polythiazide.Clinical pharmacology and therapeutics · 1978
- Polythiazide in hypertension.Southern medical journal · 1962
- Diuretic-induced hyponatremia.Annals of internal medicine · 1971
via PubMed
Wikidata facts
- Subclass of
- thiazide
- Mass
- 438.970881
- Has use
- medication
Show 5 more facts
- defined daily dose
- 1
- chemical formula
- C₁₁H₁₃ClF₃N₃O₄S₃
- medical condition treated
- arterial hypertension
- canonical SMILES
- CN1C(NC2=CC(=C(C=C2S1(=O)=O)S(=O)(=O)N)Cl)CSCC(F)(F)F
- Commons category
- Polythiazide
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 376114224 | IUPAC_name = 6-chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)thio]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide | image = Polythiazide.svg | image_class = skin-invert-image | width = 250 | image2 = Polythiazide molecule spacefill.png | image_class2 = bg-transparent | alt2 = Space-filling model of the polythiazide molecule
| tradename = | Drugs.com = | MedlinePlus = a601101 | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration =
Excerpted from Wikipedia’s “polythiazide” article, available under the CC BY-SA 4.0 licence.
Available in 9 languages
via Wikidata sitelinks · CC0