Structure via PubChem · Public domain (PubChem)
buthiazide
Sign in to saveAlso known as butizide, thiabutazide
Butizide (or thiabutazide) is a diuretic of the thiazide class.
In the Vinony graph
Vinony's link graph records 75 inbound references to buthiazide, and connects out to biological half-life, collecting duct system and liver.
It is catalogued under topics including Chemical pages without DrugBank identifier, Drugs with no legal status and ECHA InfoCard ID from Wikidata.
Vinony links it to 7 Wikipedia language editions.
Chemical data
- Formula
- C11H16ClN3O4S2
- Molecular weight
- 353.8 g/mol
- IUPAC name
- 6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
- SMILES
- CC(C)CC1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
- InChIKey
- HGBFRHCDYZJRAO-UHFFFAOYSA-N
- XLogP
- 1.1
- Polar surface area
- 135 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
43 papers- A Stability Study of Buthiazide, Mebutizide, and Bemethizide in Urinary and Aqueous Matrices.Rapid communications in mass spectrometry : RCM · 2026
- Enantiomers of benzothiadiazine diuretics by direct chromatographic resolution of the racemic drugs.Journal of pharmaceutical sciences · 1985
- Adduct formation by coeluting endogenous biomolecules using ESI-MS : A comprehensive study on ESI efficiency.Analytical and bioanalytical chemistry · 2025
- Ex vivo antigen preparation for the serological detection of drug-dependent antibodies in immune haemolytic anaemias.British journal of haematology · 1984
- European experience with spironolactone and thiazide diuretic as antihypertensive therapy.The American journal of cardiology · 1990
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 353.027
Show 3 more facts
- chemical formula
- C₁₁H₁₆ClN₃O₄S₂
- canonical SMILES
- CC(C)CC1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
- subject has role
- diuretic
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Adverse effects
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Chemistry
- Synthesis
- References
Butizide (or thiabutazide) is a diuretic of the thiazide class.
==Medical uses== Butizide is used in combination with the potassium-sparing diuretic spironolactone for the second-line treatment of edema caused by heart failure, and for difficult cases of hypertension.
Excerpted from Wikipedia’s “buthiazide” article, available under the CC BY-SA 4.0 licence.
Available in 7 languages
via Wikidata sitelinks · CC0