Structure via PubChem · Public domain (PubChem)
butenafine
Sign in to saveAlso known as 4-Tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine, (4-Tert-butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine, (4-Tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine, N-(P-Tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine, butenafina, Butenafinum, Butenafina
Butenafine, sold under the brand names Lotrimin Ultra, Mentax, and Butop (In India only), is a synthetic benzylamine derived antifungal drug.
In the Vinony graph
Within Vinony's link graph, butenafine is referenced by 101 other articles, and connects out to antifungal, Squalene epoxidase and India.
Vinony files it under 1-Naphthyl compounds, Antifungals and Drugs with non-standard legal status.
Its subject is documented across 17 Wikipedia language editions.
Key facts
- Drug.verifiedrevid
- 459987694
- Drug.IUPAC_name
- [(4-tert-butylphenyl)methyl](methyl)(naphthalen-1-ylmethyl)amine
- Drug.image
- Butenafine.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Mentax, Lotrimin Ultra
- Drug.pregnancy_US
- C
- Drug.legal_status
- OTC (Lotrimin Ultra), Rx-only (Mentax)
- Drug.routes_of_administration
- Topical (cream)
- Drug.metabolism
- Hepatic
- Drug.elimination_half life
- 35–100 hours
- Drug.CAS_number
- 101828-21-1
- Drug.ATC_prefix
- D01
- Drug.ATC_suffix
- AE23
- Drug.PubChem
- 2484
- Drug.DrugBank
- DB01091
- Drug.ChemSpiderID
- 2390
- Drug.UNII
- 91Y494NL0X
- Drug.KEGG
- D07596
via Wikipedia infobox
Chemical data
- Formula
- C23H27N
- Molecular weight
- 317.5 g/mol
- IUPAC name
- 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine
- SMILES
- CC(C)(C)C1=CC=C(C=C1)CN(C)CC2=CC=CC3=CC=CC=C32
- InChIKey
- ABJKWBDEJIDSJZ-UHFFFAOYSA-N
- XLogP
- 6.3
- Polar surface area
- 3.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1996
- Admin. routes
- topical
- Indications
- tinea pedis
via ChEMBL · EBI
Research
124 papers- Butenafine.2006
- Butenafine.Drugs · 1998
- Butenafine hydrochloride: for the treatment of interdigital tinea pedis.Expert opinion on pharmacotherapy · 2000
- Diagnosis and management of tinea infections.American family physician · 2014
- Nanoemulsified Butenafine for Enhanced Performance against Experimental Cutaneous Leishmaniasis.Journal of immunology research · 2021
via PubMed
Wikidata facts
- Subclass of
- benzylamine
- Mass
- 317.21435
- Has use
- medication
Show 6 more facts
- subject has role
- antifungal
- chemical formula
- C₂₃H₂₇N
- Commons category
- Butenafine
- medical condition treated
- pityriasis versicolor
- canonical SMILES
- CC(C)(C)C1=CC=C(C=C1)CN(C)CC2=CC=CC3=CC=CC=C32
- World Health Organisation international non-proprietary name
- butenafine
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- Available forms
- Pharmacology
- Chemistry
- Synthesis
- References
Butenafine, sold under the brand names Lotrimin Ultra, Mentax, and Butop (In India only), is a synthetic benzylamine derived antifungal drug.
It is structurally related to the allylamine antifungals terbinafine & naftifine.
Excerpted from Wikipedia’s “butenafine” article, available under the CC BY-SA 4.0 licence.