Structure via PubChem · Public domain (PubChem)
chlorothiazide
Sign in to saveAlso known as 6-chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide, 6-chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide
Chlorothiazide, sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an antihypertensive.
In the Vinony graph
Within Vinony's link graph, chlorothiazide is referenced by 115 other articles, and connects out to heart failure, sulfonamide drug and collecting duct system.
Vinony files it under Benzothiadiazines, Carbonic anhydrase inhibitors and Drugs developed by Merck & Co..
Its subject is documented across 22 Wikipedia language editions.
Chemical data
- Formula
- C7H6ClN3O4S2
- Molecular weight
- 295.7 g/mol
- IUPAC name
- 6-chloro-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
- SMILES
- C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2
- InChIKey
- JBMKAUGHUNFTOL-UHFFFAOYSA-N
- XLogP
- -0.2
- Polar surface area
- 135 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1958
- Admin. routes
- oral, parenteral
- Indications
- hypertension, nephrotic syndrome, congestive heart failure, cardiovascular disease
via ChEMBL · EBI
Research
9,337 papers- Chlorothiazide.British journal of clinical pharmacology · 1982
- Chlorothiazide.Neonatal network : NN · 1993
- CHLOROTHIAZIDE.Journal of the Indian Medical Association · 1959
- [Chlorothiazide].Anales de farmacia hospitalaria · 1960
- [Chlorothiazide diuretics].Lekarska veda v zahranici · 1960
via PubMed
Wikidata facts
- Subclass of
- thiazide
- Has part
- sulfur
- Mass
- 294.948825
- Has use
- medication
Show 6 more facts
- Commons category
- Chlorothiazide
- chemical formula
- C₇H₆ClN₃O₄S₂
- subject has role
- antihypertensive drug
- canonical SMILES
- C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2
- World Health Organisation international non-proprietary name
- chlorothiazide
- defined daily dose
- 0.5
Sources (8)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Indications
- Contraindications
- Side effects
- History
- See also
- References
Chlorothiazide, sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an antihypertensive.
It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism from furosemide and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another.
Excerpted from Wikipedia’s “chlorothiazide” article, available under the CC BY-SA 4.0 licence.