PRLR

Name

prolactin receptor

Type

protein-coding

Position

35,048,756–35,230,533 (−)

Aliases

HPRL, MFAB, RI-PRLR, hPRLrI

Ensembl

ENSG00000113494

RefSeq RNA

NM_000949.7, NM_001204314.2, NM_001204315.1, NM_001204316.1, NM_001204317.1

RefSeq protein

NP_000940.1, NP_001191243.1, NP_001191244.1, NP_001191245.1, NP_001191246.1

This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011].