procarbazine

Also known as Matulane®, Ro-4-6467/1, Ro-4646711, N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide, p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide, N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide, 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine, N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine

Procarbazine is a chemotherapy medication used for the treatment of Hodgkin lymphoma and brain cancers. For Hodgkin lymphoma it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and vincristine. It is typically taken by mouth.

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 464214923
Drug.IUPAC_name: N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide
Drug.image: Procarbazine.svg
Drug.image_class: skin-invert-image
Drug.width: 180px
Drug.image2: Procarbazine ball-and-stick.png
Drug.image_class2: bg-transparent
Drug.width2: 180px
Drug.tradename: Matulane, Natulan, Indicarb, others
Drug.MedlinePlus: a682094

Article

5 sections

Contents

Medical uses
Side effects
Pharmacology
References
External links

Common side effect include low blood cell counts and vomiting. Other side effects include tiredness and depression. It is not recommended in people with severe liver or kidney problems. Use in pregnancy is known to harm the baby. Procarbazine is in the alkylating agents family of medication. How it works is not clearly known.