Structure via PubChem · Public domain (PubChem)
procarbazine
Sign in to saveAlso known as Matulane®, Ro-4-6467/1, Ro-4646711, N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide, p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide, N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide, 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine, N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine
Procarbazine is a chemotherapy medication used for the treatment of Hodgkin lymphoma and brain cancers. For Hodgkin lymphoma it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and vincristine. It is typically taken by mouth.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 464214923
- Drug.IUPAC_name
- N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide
- Drug.image
- Procarbazine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 180px
- Drug.image2
- Procarbazine ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 180px
- Drug.tradename
- Matulane, Natulan, Indicarb, others
- Drug.MedlinePlus
- a682094
- Drug.pregnancy_AU
- D
- Drug.pregnancy_US
- D
- Drug.legal_status
- Rx-only
- Drug.routes_of_administration
- By mouth (gel capsule), intravenous
- Drug.metabolism
- liver, kidney
- Drug.elimination_half life
- 10 minutes
via Wikipedia infobox
Chemical data
- Formula
- C12H19N3O
- Molecular weight
- 221.3 g/mol
- IUPAC name
- 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide
- SMILES
- CC(C)NC(=O)C1=CC=C(C=C1)CNNC
- InChIKey
- CPTBDICYNRMXFX-UHFFFAOYSA-N
- XLogP
- 0.1
- Polar surface area
- 53.2 Ų
- H-bond donors
- 3
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
4,373 papers- Procarbazine--a traditional drug in the treatment of malignant gliomas.Current medicinal chemistry · 2008
- Procarbazine-induced hepatotoxicity: case report and review of the literature.Pharmacotherapy · 2010
- Procarbazine lung.AJR. American journal of roentgenology · 1978
- Drugs 5 years later: procarbazine.Annals of internal medicine · 1974
- Procarbazine for non-Hodgkin's lymphoma.Leukemia & lymphoma · 2006
via PubMed
Wikidata facts
- Mass
- 221.152812
Show 4 more facts
- Commons category
- Procarbazine
- chemical formula
- C₁₂H₁₉N₃O
- canonical SMILES
- CC(C)NC(=O)C1=CC=C(C=C1)CNNC
- World Health Organisation international non-proprietary name
- procarbazine
via Wikidata · CC0
~4 min read
Article
5 sectionsContents
- Medical uses
- Side effects
- Pharmacology
- References
- External links
Procarbazine is a chemotherapy medication used for the treatment of Hodgkin lymphoma and brain cancers. For Hodgkin lymphoma it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and vincristine. It is typically taken by mouth.
Common side effect include low blood cell counts and vomiting. Other side effects include tiredness and depression. It is not recommended in people with severe liver or kidney problems. Use in pregnancy is known to harm the baby. Procarbazine is in the alkylating agents family of medication. How it works is not clearly known.