procyclidine

Also known as 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol, 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol, 1-cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol, 1-cyclohexyl-1-phenyl-3-pyrrolidino-propan-1-ol, 1-cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol

Procyclidine is an anticholinergic drug principally used for the treatment of drug-induced parkinsonism, akathisia and acute dystonia, Parkinson's disease, and idiopathic or secondary dystonia.

Research

289 papers

Procyclidine abuse.The British journal of psychiatry : the journal of mental science · 1986
Dystonia.BMJ clinical evidence · 2014
Teenage procyclidine abuse.Lancet (London, England) · 1985
In vivo Evaluation of Antioxidant Activity of Chamomile Extract against Procyclidine-Induced Oxidative Stress: Potential Application in Cancer Prevention.Asian Pacific journal of cancer prevention : APJCP · 2024
Effects of procyclidine on eye movements in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2003

via PubMed

Wikidata facts

Mass: 287.224915

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chemical formula: C₁₉H₂₉NO
canonical SMILES: C1CCC(CC1)C(CCN2CCCC2)(C3=CC=CC=C3)O
World Health Organisation international non-proprietary name: procyclidine
Commons category: Procyclidine
defined daily dose: 25

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Article

10 sections

Contents

Medical uses
Side effects
Overdose
Pharmacology
Pharmacodynamics
Chemistry
Synthesis
See also
References
Further reading

Procyclidine is an anticholinergic drug principally used for the treatment of drug-induced parkinsonism, akathisia and acute dystonia, Parkinson's disease, and idiopathic or secondary dystonia.

== Medical uses == It is used in patients with parkinsonism and akathisia, and to reduce the side effects of antipsychotic treatment given for schizophrenia. Procyclidine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor but not rigidity or bradykinesia.