PTCH2
Sign in to saveAlso known as PTC2, patched 2
Patched 2 is a protein that in humans is encoded by the PTCH2 gene.
Gene data
PTCH2- Name
- patched 2
- Type
- protein-coding
- Position
- 44,819,154–44,843,253 (−)
- Aliases
- PTC2, SLC65B2
- Ensembl
- ENSG00000117425
- RefSeq RNA
- NM_001166292.2, NM_003738.5
- RefSeq protein
- NP_001159764.1, NP_003729.3
This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
patched 2
- Symbol
- PTCH2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:44,819,154-44,843,253
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
Show 3 more facts
- HomoloGene ID
- 37842
- exact match
- identifiers.org/ncbigene/8643
- cytogenetic location
- 1p34.1
Sources (4)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Patched 2 is a protein that in humans is encoded by the PTCH2 gene.
==Function==
Connections
Q180686
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Ensembl genome database project
Entity
protein
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Wikidata
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gene
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chromosome
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public domain
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digital object identifier
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bibcode
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human genome
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Q229883
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base pair
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locus
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gene expression
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Online Mendelian Inheritance in Man
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human chromosome 1
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United States National Library of Medicine
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Q22908627
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basal-cell carcinoma of the skin
Entity
tumor suppressor gene
Entity