رولوفیلین

Also known as KW-3902, NAX

Rolofylline (KW-3902) is an experimental diuretic which acts as a selective adenosine A1 receptor antagonist. It was discovered at NovaCardia, Inc. which was purchased by Merck & Co., Inc. in 2007.

Chemical data

Formula: C20H28N4O2
Molecular weight: 356.5 g/mol
IUPAC name: 1,3-dipropyl-8-(3-tricyclo[3.3.1.03,7]nonanyl)-7H-purine-2,6-dione

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 3
Molecule type: Small molecule
Indications: heart failure, congestive heart failure

via ChEMBL · EBI

Research

122 papers

Rolofylline: a selective adenosine 1 receptor antagonist for the treatment of heart failure.Expert opinion on pharmacotherapy · 2009
Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure.The New England journal of medicine · 2010
Rolofylline, an adenosine A1 receptor antagonist, inhibits osteoclast differentiation as an inverse agonist.British journal of pharmacology · 2013
Simultaneous pharmacokinetic model for rolofylline and both M1-trans and M1-cis metabolites.The AAPS journal · 2013
Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280.Proceedings of the National Academy of Sciences of the United States of America · 2016

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 356.221226

Show 3 more facts

chemical formula: C₂₀H₂₈N₄O₂
canonical SMILES: CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C34CC5CC(C3)CC4C5
subject has role: diuretic

Sources (2)

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