Structure via PubChem · Public domain (PubChem)
rucaparib
Sign in to saveAlso known as AG-014699, AG014699, AG14447, PF-01367338, Rubraca
Rucaparib, sold under the brand name Rubraca, is a PARP inhibitor used as an anti-cancer agent. Rucaparib is a first-in-class pharmaceutical drug targeting the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). It is taken by mouth.
Key facts
- Drug.image
- Rucaparib.svg
- Drug.image_class
- skin-invert-image
- Drug.caption
- Above: molecular structure of rucaparib Below: 3D representation of a rucaparib molecule
- Drug.image2
- Rucaparib 3D.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Rubraca
- Drug.MedlinePlus
- a617002
- Drug.DailyMedID
- Rucaparib
- Drug.pregnancy_category
- Not recommended
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- L01
- Drug.ATC_suffix
- XK03
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.bioavailability
- 30–45% (Tmax = 1.9 hours)
- Drug.protein_bound
- 70% (in vitro)
via Wikipedia infobox
Chemical data
- Formula
- C19H18FN3O
- Molecular weight
- 323.4 g/mol
- IUPAC name
- 6-fluoro-2-[4-(methylaminomethyl)phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2016
- Admin. routes
- oral
- Indications
- neoplasm, pancreatic carcinoma, Hereditary breast and ovarian cancer syndrome, mesothelioma
via ChEMBL · EBI
Research
773 papers- Rucaparib.2006
- Rucaparib or Physician's Choice in Metastatic Prostate Cancer.The New England journal of medicine · 2023
- A Randomized, Phase III Trial to Evaluate Rucaparib Monotherapy as Maintenance Treatment in Patients With Newly Diagnosed Ovarian Cancer (ATHENA-MONO/GOG-3020/ENGOT-ov45).Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
- Rucaparib: A Review in Ovarian Cancer.Targeted oncology · 2019
- Rucaparib.2012
via PubMed
Wikidata facts
- Mass
- 323.143
Show 5 more facts
- chemical formula
- C₁₉H₁₈FN₃O
- canonical SMILES
- CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F
- World Health Organisation international non-proprietary name
- rucaparib
- NCI Thesaurus ID
- C137800
- Commons category
- Rucaparib
via Wikidata · CC0
~7 min read
Article
10 sectionsContents
- Medical uses
- Pharmacology
- Mechanism of action
- History
- Society and culture
- Legal status
- Research
- Clinical trials
- References
- External links
{{Infobox drug | image = Rucaparib.svg | image_class = skin-invert-image | alt = | caption = Above: molecular structure of rucaparib Below: 3D representation of a rucaparib molecule | image2 = Rucaparib 3D.png | image_class2 = bg-transparent | alt2 =
| pronounce = | tradename = Rubraca | Drugs.com = | MedlinePlus = a617002 | DailyMedID = Rucaparib | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category = Not recommended | routes_of_administration = By mouth | class = | ATC_prefix = L01 | ATC_suffix = XK03 | ATC_supplemental =
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via Wikidata sitelinks · CC0