sabcomeline
Sign in to saveAlso known as SB-202026
Sabcomeline (Memric; SB-202,026) is a selective M1 receptor partial agonist that was under development for the treatment of Alzheimer's disease. It made it to phase III clinical trials before being discontinued due to poor results.
Wikidata facts
- Mass
- 193.121512
Show 4 more facts
- chemical formula
- C₁₀H₁₅N₃O
- isomeric SMILES
- CO/N=C(\C#N)/[C@H]1CN2CCC1CC2
- canonical SMILES
- CON=C(C#N)C1CN2CCC1CC2
- Commons category
- Sabcomeline
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- See also
- References
Sabcomeline (Memric; SB-202,026) is a selective M1 receptor partial agonist that was under development for the treatment of Alzheimer's disease. It made it to phase III clinical trials before being discontinued due to poor results.
It is a non-selective agonist of all five muscarinic acetylcholine receptors with similar affinities. However, functional selectivity for the M1 receptor has been claimed in vitro and in vivo.
Connections
atropine
Entity
muscarinic acetylcholine receptor family
Entity
Alzheimer's disease
Entity
digital object identifier
Entity
dementia
Entity
chemical formula
Entity
Ginkgo biloba
Entity
molar mass
Entity
Q180686
Entity
acetylcholine
Entity
CAS Registry Number
Entity
Mamba
Entity
Q229883
Entity
PubChem
Entity
Anatomical Therapeutic Chemical Classification System
Entity
choline
Entity
in vitro experiment
Entity
amitriptyline
Entity
L-scopolamine
Entity
in vivo
Entity
Categories
Abandoned drugsChemical articles with multiple CAS registry numbersChemical pages without DrugBank identifierChemicals using indexlabelsDrugs not assigned an ATC codeDrugs with non-standard legal statusExperimental drugsKetoxime ethersM1 receptor agonistsM2 receptor agonistsM3 receptor agonistsM4 receptor agonistsM5 receptor agonistsMultiple chemicals in Infobox drugNitrilesQuinuclidines