selexipag
Sign in to saveAlso known as ACT-293987, NS-304, Uptravi®, NS 304, ACT 293987
Selexipag, sold under the brand name Uptravi, is a medication developed by Actelion for the treatment of pulmonary arterial hypertension (PAH). Selexipag and its active metabolite, ACT-333679 (or MRE-269, the free carboxylic acid), are agonists of the prostacyclin receptor, which leads to vasodilation in the pulmonary circulation. It is taken by mouth or administered intravenously.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 444391072
- Drug.image
- Selexipag.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Uptravi
- Drug.DailyMedID
- Selexipag
- Drug.routes_of_administration
- By mouth, intravenous
- Drug.class
- prostacyclin receptor agonist
- Drug.ATC_prefix
- B01
- Drug.ATC_suffix
- AC27
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.bioavailability
- 49%
- Drug.protein_bound
- 99%
- Drug.metabolism
- Activation by carboxylesterases, inactivation by CYP2C8 and others
- Drug.metabolites
- ACT-333679, the free acid (active metabolite)
via Wikipedia infobox
Research
368 papers- Selexipag for the Treatment of Pulmonary Arterial Hypertension.The New England journal of medicine · 2015
- Selexipag.2006
- Selexipag.2012
- Selexipag for the Treatment of Pediatric Pulmonary Hypertension: A Systematic Review.Clinical therapeutics · 2024
- Selexipag for pulmonary arterial hypertension.Australian prescriber · 2021
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 496.214427
- Has use
- medication
Show 8 more facts
- chemical formula
- C₂₆H₃₂N₄O₄S
- defined daily dose
- 1.8
- canonical SMILES
- CC(C)N(CCCCOCC(=O)NS(=O)(=O)C)C1=CN=C(C(=N1)C2=CC=CC=C2)C3=CC=CC=C3
- World Health Organisation international non-proprietary name
- selexipag
- medical condition treated
- pulmonary hypertension
- subject has role
- antihypertensive drug
- physically interacts with
- Prostaglandin I2 receptor
- Commons category
- Selexipag
via Wikidata · CC0
~6 min read
Encyclopedic overview
13 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Chemistry
- Synthesis
- History
- Society and culture
- Economics
- References
- External links
{{Infobox drug | Verifiedfields = changed | verifiedrevid = 444391072 | image = Selexipag.svg | image_class = skin-invert-image | width = | alt = | caption =
| pronounce = | tradename = Uptravi | Drugs.com = | MedlinePlus = | DailyMedID = Selexipag | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = By mouth, intravenous | class = prostacyclin receptor agonist | ATC_prefix = B01 | ATC_suffix = AC27 | ATC_supplemental =
Excerpted from Wikipedia’s “selexipag” article, available under the CC BY-SA 4.0 licence.
Gallery (2)
Available in 12 languages
via Wikidata sitelinks · CC0