SGCB

Also known as A3b, LGMD2E, SGC, sarcoglycan beta, LGMDR4

Beta-sarcoglycan is a protein that in humans is encoded by the SGCB gene.

Gene data

SGCB

Name: sarcoglycan beta
Type: protein-coding
Aliases: A3b, LGMD2E, LGMDR4, SGC

This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008].

via MyGene.info

Gene · Ensembl

sarcoglycan beta

Symbol: SGCB
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:52,020,697-52,038,305
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 195
exact match: identifiers.org/ncbigene/6443
genomic end: 52038299
genomic start: 52886872
cytogenetic location: 4q12

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Beta-sarcoglycan is a protein that in humans is encoded by the SGCB gene.

The dystrophin-glycoprotein complex (DGC) is a multisubunit protein complex that spans the sarcolemma and provides structural linkage between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. There are 3 main subcomplexes of the DGC: the cytoplasmic proteins dystrophin (DMD; MIM 300377) and syntrophin (SNTA1; MIM 601017), the alpha- and beta-dystroglycans (see MIM 128239), and the sarcoglycans (see, e.g., SGCA; MIM 600119) (Crosbie et al., 2000).[supplied by OMIM].