SH2B3
Sign in to saveAlso known as IDDM20, LNK, SH2B adaptor protein 3
SH2B adapter protein 3 (SH2B3), also known as lymphocyte adapter protein (LNK), is a protein that in humans is encoded by the SH2B3 gene on chromosome 12. SH2B3 is ubiquitously expressed in many tissues and cell types. LNK functions as a regulator in signaling pathways relating to hematopoiesis, inflammation, and cell migration. As a result, it is involved in blood diseases, autoimmune disorders, and vascular disease. The SH2B3 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.
In the Vinony graph
Vinony's link graph records 11 inbound references to SH2B3, and connects out to PubMed, Ensembl genome database project and platelet formation.
It is catalogued under the topic Genes on human chromosome 12.
Vinony links it to 6 Wikipedia language editions.
Gene data
SH2B3- Name
- SH2B adaptor protein 3
- Type
- protein-coding
- Aliases
- IDDM20, LNK
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014].
via MyGene.info
Gene · Ensembl
SH2B adaptor protein 3
- Symbol
- SH2B3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:111,404,986-111,451,623
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 36179
- genetic association
- rheumatoid arthritis
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10019
- genomic end
- 111889427
- genomic start
- 111405923
- chromosome
- human chromosome 12
- cytogenetic location
- 12q24.12
- expressed in
- appendix
via Wikidata · CC0
~5 min read
Encyclopedic overview
10 sectionsContents
- Structure
- Gene
- Protein
- Function
- Interactions
- Clinical significance
- Clinical marker
- References
- Further reading
- External links
SH2B adapter protein 3 (SH2B3), also known as lymphocyte adapter protein (LNK), is a protein that in humans is encoded by the SH2B3 gene on chromosome 12. SH2B3 is ubiquitously expressed in many tissues and cell types. LNK functions as a regulator in signaling pathways relating to hematopoiesis, inflammation, and cell migration. As a result, it is involved in blood diseases, autoimmune disorders, and vascular disease. The SH2B3 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.
== Structure ==
Excerpted from Wikipedia’s “SH2B3” article, available under the CC BY-SA 4.0 licence.