SKIL
Sign in to saveAlso known as SNO, SnoA, SnoI, SnoN, SKI-like proto-oncogene, SKI like proto-oncogene
Ski-like protein is a protein that in humans is encoded by the SKIL gene.
In the Vinony graph
Within Vinony's link graph, SKIL is referenced by 5 other articles, and connects out to PubMed, human chromosome 3 and Ensembl genome database project.
It is catalogued under topics including Genes on human chromosome 3 and Proteins.
Its subject is documented across 6 Wikipedia language editions.
Gene data
SKIL- Name
- SKI like proto-oncogene
- Type
- protein-coding
- Position
- 170,357,287–170,396,848 (+)
- Aliases
- SNO, SnoA, SnoI, SnoN
- Ensembl
- ENSG00000136603
- RefSeq RNA
- NM_001145097.2, NM_001145098.3, NM_001248008.1, NM_005414.5, XM_005247721.2
- RefSeq protein
- NP_001138569.1, NP_001138570.1, NP_001234937.1, NP_005405.2, XP_005247778.1
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SKI like proto-oncogene
- Symbol
- SKIL
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:170,357,287-170,396,848
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- SNON protein.png
Show 8 more facts
- HomoloGene ID
- 3948
- genomic end
- 170396835
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6498
- genomic start
- 170075466
- chromosome
- human chromosome 3
- cytogenetic location
- 3q26.2
- expressed in
- superficial temporal artery
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- Protein Family
- References
- Further reading
Ski-like protein is a protein that in humans is encoded by the SKIL gene.
==Interactions== SKIL interacts with SKI protein, Mothers against decapentaplegic homolog 3 and Mothers against decapentaplegic homolog 2.
Excerpted from Wikipedia’s “SKIL” article, available under the CC BY-SA 4.0 licence.