SPI1

Also known as OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene, AGM10

Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.

Gene data

SPI1

Name: Spi-1 proto-oncogene
Type: protein-coding
Position: 47,354,860–47,409,369 (−)
Aliases: AGM10, OF, PU.1, SFPI1, SPI-1, SPI-A
Ensembl: ENSG00000066336
RefSeq RNA: NM_001080547.2, NM_003120.3, XM_054369738.1, XM_054369739.1
RefSeq protein: NP_001074016.1, NP_003111.2, XP_054225713.1, XP_054225714.1

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II

~2 min read

Article

6 sections

Contents

Function
Structure
Interactions
References
Further reading
External links

Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.

== Function == This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found on enhancers of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.