PTF1A
Sign in to saveAlso known as PACA, PAGEN2, PTF1-p48, bHLHa29, pancreas specific transcription factor, 1a, p48, pancreas associated transcription factor 1a
Pancreas transcription factor 1 subunit alpha is a protein that in humans is encoded by the PTF1A gene.
In the Vinony graph
Within Vinony's link graph, PTF1A is referenced by 8 other articles, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 10.
Its subject is documented across 5 Wikipedia language editions.
Gene data
PTF1A- Name
- pancreas associated transcription factor 1a
- Type
- protein-coding
- Position
- 23,192,305–23,194,245 (+)
- Aliases
- PACA, PAGEN2, PTF1-p48, bHLHa29, p48
- Ensembl
- ENSG00000168267
- RefSeq RNA
- NM_178161.3
- RefSeq protein
- NP_835455.1
This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
pancreas associated transcription factor 1a
- Symbol
- PTF1A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:23,192,305-23,194,245
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 10304
- chromosome
- human chromosome 10
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/256297
- genomic end
- 23194245
- genomic start
- 23192312
- cytogenetic location
- 10p12.2
- expressed in
- nucleus accumbens
Sources (6)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Pancreas transcription factor 1 subunit alpha is a protein that in humans is encoded by the PTF1A gene.
== Function ==
Excerpted from Wikipedia’s “PTF1A” article, available under the CC BY-SA 4.0 licence.