PURB
Sign in to saveAlso known as PURBETA, purine-rich element binding protein B, purine rich element binding protein B
Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.
Gene data
PURB- Name
- purine rich element binding protein B
- Type
- protein-coding
- Position
- 44,876,299–44,885,530 (−)
- Aliases
- PURBETA
- Ensembl
- ENSG00000146676
- RefSeq RNA
- NM_033224.5
- RefSeq protein
- NP_150093.1
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
purine rich element binding protein B
- Symbol
- PURB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:44,876,299-44,885,530
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 69087
- exact match
- identifiers.org/ncbigene/5814
- genomic end
- 44885530
- genomic start
- 44876299
- cytogenetic location
- 7p13
Sources (4)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans.