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GeneQ18031670· pop 6· linked from 815 articles

SPIB

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Also known as SPI-B, Spi-B transcription factor

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.

Gene data

SPIB

Name: Spi-B transcription factor
Type: protein-coding
Position: 50,418,938–50,431,314 (+)
Aliases: SPI-B
Ensembl: ENSG00000269404
RefSeq RNA: NM_001243998.2, NM_001243999.2, NM_001244000.2, NM_003121.5
RefSeq protein: NP_001230927.1, NP_001230928.1, NP_001230929.2, NP_003112.2

The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

Gene Ontology

Biological process

immature B cell differentiation regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II cell differentiation positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity protein binding sequence-specific DNA binding sequence-specific double-stranded DNA binding

Cellular component

chromatin nucleus nucleus cytoplasm cytoplasm

via MyGene.info

Gene · Ensembl

Spi-B transcription factor

Symbol: SPIB
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:50,418,931-50,431,314
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 79220
exact match: identifiers.org/ncbigene/6689
genomic start: 50922195
genomic end: 50431314
cytogenetic location: 19q13.33

Sources (6)

via Wikidata · CC0

~1 min read

Article

5 sections

Contents

Function
Interactions
References
Further reading
External links

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.

== Function ==

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Categories

Genes on human chromosome 19 Transcription factors