Structure via PubChem · Public domain (PubChem)
اسپیراپریل
Sign in to saveAlso known as Renormax®, SCH-33844
Spirapril, sold under the brand name Renormax among others, is an ACE inhibitor antihypertensive drug used to treat hypertension. It belongs to dicarboxy group of ACE inhibitors.
Chemical data
- Formula
- C22H30N2O5S2
- Molecular weight
- 466.6 g/mol
- IUPAC name
- (8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
- SMILES
- CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3(C[C@H]2C(=O)O)SCCS3
- InChIKey
- HRWCVUIFMSZDJS-SZMVWBNQSA-N
- XLogP
- 0.9
- Polar surface area
- 147 Ų
- H-bond donors
- 2
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1994
- Admin. routes
- oral
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
147 papers- Spirapril. A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension.Drugs · 1995
- Efficacy and safety of spirapril in mild-to-moderate hypertension.Journal of cardiovascular pharmacology · 1999
- Angiotensin-converting enzyme inhibitor induced cough compared with placebo, and other antihypertensives: A systematic review, and network meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2023
- Comparison of efficacy of spirapril and enalapril in control of mild-to-moderate hypertension.Cardiovascular drugs and therapy · 1997
- ACE inhibition in chronic renal failure and in the treatment of diabetic nephropathy: focus on spirapril.Journal of cardiovascular pharmacology · 1999
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 466.16
- Has use
- medication
Show 6 more facts
- chemical formula
- C₂₂H₃₀N₂O₅S₂
- canonical SMILES
- CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3(CC2C(=O)O)SCCS3
- isomeric SMILES
- CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3(C[C@H]2C(=O)O)SCCS3
- defined daily dose
- 6
- Commons category
- Spirapril
- subject has role
- ACE inhibitor
Sources (3)
via Wikidata · CC0