STK3

Also known as KRS1, MST2, serine/threonine kinase 3

Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene.

Gene data

STK3

Name: serine/threonine kinase 3
Type: protein-coding
Aliases: KRS1, MST2

This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].

via MyGene.info

Gene · Ensembl

serine/threonine kinase 3

Symbol: STK3
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:98,371,228-98,942,827
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Structure of the human STK3 kinase domain.png

Show 6 more facts

HomoloGene ID: 48420
exact match: identifiers.org/ncbigene/6788
genomic end: 99955055
genomic start: 98371228
cytogenetic location: 8q22.2
Commons category: Serine/threonine-protein kinase 3

Sources (4)

via Wikidata · CC0

~4 min read

Article

10 sections

Contents

Background
Structure
Mechanism
Activation
Inactivation
MST2 substrates
Disease Relevance
References
Further reading
External links

Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene.

== Background == Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was first identified as a kinase that resembles budding yeast Ste20 (Creasy and Chernoff, 1996) and later as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996; Lee et al., 2001).[supplied by OMIM]