AKT3

Also known as MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2

RAC-gamma serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT3 gene.

Gene data

AKT3

Name: AKT serine/threonine kinase 3
Type: protein-coding
Position: 243,488,233–243,851,079 (−)
Aliases: MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2
Ensembl: ENSG00000117020
RefSeq RNA: NM_001206729.2, NM_001370074.1, NM_005465.7, NM_181690.2, XM_011544014.3
RefSeq protein: NP_001193658.1, NP_001357003.1, NP_005456.1, NP_859029.1, XP_011542316.1

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].