STMN1

Also known as C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN

Stathmin, also known as metablastin and oncoprotein 18 is a protein that in humans is encoded by the STMN1 gene.

Gene data

STMN1

Name: stathmin 1
Type: protein-coding
Position: 25,884,181–25,907,237 (−)
Aliases: C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN
Ensembl: ENSG00000117632
RefSeq RNA: NM_001145454.3, NM_005563.4, NM_152497.1, NM_203399.2, NM_203401.2
RefSeq protein: NP_001138926.1, NP_005554.1, NP_981944.1, NP_981946.1

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].

Pathways

MAPK signaling pathway - Homo sapiens (human)MicroRNAs in cancer - Homo sapiens (human)Signaling by ERBB4 Nuclear signaling by ERBB4 Signal Transduction Signaling by Receptor Tyrosine Kinases Regulation of Microtubule Cytoskeleton Retinoblastoma gene in cancer RAC1-PAK1-p38-MMP2 Pathway MAPK Signaling Pathway

via MyGene.info

Gene · Ensembl

stathmin 1

Symbol: STMN1
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:25,884,181-25,908,470
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 4063
exact match: identifiers.org/ncbigene/3925
genomic end: 26233482
genomic start: 26210672
cytogenetic location: 1p36.11

Sources (5)

via Wikidata · CC0

~5 min read

Article

8 sections

Contents

Structure
Function
Interactions
Clinical significance
Role in social behaviour
References
Further reading
External links

Stathmin, also known as metablastin and oncoprotein 18 is a protein that in humans is encoded by the STMN1 gene.

Stathmin is a highly conserved 17 kDa protein that is crucial for the regulation of the cell cytoskeleton. Changes in the cytoskeleton are important because the cytoskeleton is a scaffold required for many cellular processes, such as cytoplasmic organization, cell division and cell motility. More specifically, stathmin is crucial in regulating the cell cycle. It is found solely in eukaryotes.