Also known as P15, PC4, p14, SUB1 homolog, transcriptional regulator, SUB1 regulator of transcription
Activated RNA polymerase II transcriptional coactivator p15 also known as positive cofactor 4 (PC4) or SUB1 homolog is a protein that in humans is encoded by the SUB1 gene. The human SUB1 gene is named after an orthologous gene in yeast.
Enables identical protein binding activity; single-stranded DNA binding activity; and transcription coactivator activity. Involved in negative regulation of DNA metabolic process and regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]
Activated RNA polymerase II transcriptional coactivator p15 also known as positive cofactor 4 (PC4) or SUB1 homolog is a protein that in humans is encoded by the SUB1 gene. The human SUB1 gene is named after an orthologous gene in yeast.
SUB1 is induced by oxidative stress, and is involved in coordinating cellular responses to DNA strand breaks that arise after oxidative stress. Yeast SUB1 has structural and functional similarities to human alpha-synuclein, a protein that has an important role in Parkinson's disease. Like SUB1, alpha-synuclein functions in regulating DNA repair including repair of DNA double-strand breaks.
via MyGene.info
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).