SUB1

Also known as P15, PC4, p14, SUB1 homolog, transcriptional regulator, SUB1 regulator of transcription

Activated RNA polymerase II transcriptional coactivator p15 also known as positive cofactor 4 (PC4) or SUB1 homolog is a protein that in humans is encoded by the SUB1 gene. The human SUB1 gene is named after an orthologous gene in yeast.

Gene data

SUB1

Name: SUB1 regulator of transcription
Type: protein-coding
Position: 32,531,633–32,604,507 (+)
Aliases: P15, PC4, p14
Ensembl: ENSG00000113387
RefSeq RNA: NM_006713.4, XM_011513944.4, XM_047416661.1
RefSeq protein: NP_006704.3, XP_011512246.1, XP_047272617.1

Enables identical protein binding activity; single-stranded DNA binding activity; and transcription coactivator activity. Involved in negative regulation of DNA metabolic process and regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

via MyGene.info

Gene · Ensembl

SUB1 regulator of transcription

Symbol: SUB1
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:32,505,893-32,604,507
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein SUB1 PDB 1pcf.png

Show 5 more facts

HomoloGene ID: 38218
exact match: identifiers.org/ncbigene/10923
genomic end: 32604185
genomic start: 32531739
cytogenetic location: 5p13.3

Sources (4)

via Wikidata · CC0

~1 min read

Article

4 sections

Contents

Interactions
References
Further reading
External links

SUB1 is induced by oxidative stress, and is involved in coordinating cellular responses to DNA strand breaks that arise after oxidative stress. Yeast SUB1 has structural and functional similarities to human alpha-synuclein, a protein that has an important role in Parkinson's disease. Like SUB1, alpha-synuclein functions in regulating DNA repair including repair of DNA double-strand breaks.