SUFU
Sign in to saveAlso known as PRO1280, SUFUH, SUFUXL, SUFU negative regulator of hedgehog signaling, JBTS32
Suppressor of fused homolog is a protein that in humans is encoded by the SUFU gene. In molecular biology, the protein domain suppressor of fused protein (Sufu) has an important role in the cell. The Sufu is important in negatively regulating an important signalling pathway in the cell, the Hedgehog signalling pathway (HH). This particular pathway is crucial in embryonic development. There are several homologues of Sufu, found in a wide variety of organisms.
In the Vinony graph
Vinony's link graph records 8 inbound references to SUFU, and connects out to PubMed, transcription factor and cell signaling.
It is catalogued under the topic Genes on human chromosome 10.
Vinony links it to 8 Wikipedia language editions.
Gene data
SUFU- Name
- SUFU negative regulator of hedgehog signaling
- Type
- protein-coding
- Position
- 102,503,952–102,633,535 (+)
- Aliases
- BCNS2, JBTS32, PRO1280, SUFUH, SUFUXL
- Ensembl
- ENSG00000107882
- RefSeq RNA
- NM_001178133.2, NM_016169.4, XM_011539858.4, XM_011539860.4, XM_011539861.4
- RefSeq protein
- NP_001171604.1, NP_057253.2, XP_011538160.1, XP_011538162.1, XP_011538163.1
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SUFU negative regulator of hedgehog signaling
- Symbol
- SUFU
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:102,503,952-102,633,535
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SUFU PDB 1m1l.png
Show 7 more facts
- HomoloGene ID
- 9262
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/51684
- genomic start
- 102503972
- chromosome
- human chromosome 10
- genomic end
- 104393292
- cytogenetic location
- 10q24.32
via Wikidata · CC0
~2 min read
Encyclopedic overview
8 sectionsContents
- Function
- Interactions
- Conservation
- Structure
- Genes
- References
- Further reading
- External links
Suppressor of fused homolog is a protein that in humans is encoded by the SUFU gene. In molecular biology, the protein domain suppressor of fused protein (Sufu) has an important role in the cell. The Sufu is important in negatively regulating an important signalling pathway in the cell, the Hedgehog signalling pathway (HH). This particular pathway is crucial in embryonic development. There are several homologues of Sufu, found in a wide variety of organisms.
== Function ==
Excerpted from Wikipedia’s “SUFU” article, available under the CC BY-SA 4.0 licence.