suprofene

Also known as Profenal®, R-25061, (+-)-2-(p-(2-thenoyl)phenyl)propionic acid, alpha-methyl-4-(2-thienylcarbonyl)benzeneacetic acid, p-2-thenoylhydratropic acid, 2-[4-(Thiophene-2-carbonyl)-phenyl]-propionic acid, Suprofène

farmaco

In the Vinony graph

Within Vinony's link graph, suprofene is referenced by 491 other articles, and connects out to salicylic acid, metamizole sodium and clonixin.

It is catalogued under topics including Aromatic ketones, Drugboxes which contain changes to verified fields and Drugboxes which contain changes to watched fields.

Its subject is documented across 7 Wikipedia language editions.

Chemical data

Formula: C14H12O3S
Molecular weight: 260.31 g/mol
IUPAC name: 2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid
SMILES: CC(C1=CC=C(C=C1)C(=O)C2=CC=CS2)C(=O)O
InChIKey: MDKGKXOCJGEUJW-UHFFFAOYSA-N
XLogP: 3.3
Polar surface area: 82.6 Å²
H-bond donors: 1
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Withdrawn

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1985
Admin. routes: topical
Indications: rheumatic disease

via ChEMBL · EBI

Research

320 papers

Suprofen. A review of its pharmacodynamic and pharmacokinetic properties, and analgesic efficacy.Drugs · 1985
Introduction to the pharmacology of suprofen.Pharmacology · 1983
Suprofen.The Medical letter on drugs and therapeutics · 1986
Suprofen: the pharmacology and clinical efficacy of a new non-narcotic peripheral analgesic.Clinics in rheumatic diseases · 1984
Suprofen, a new peripheral analgesic.The Journal of pharmacology and experimental therapeutics · 1980

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 260.050715
Has use: medication

Show 6 more facts

chemical formula: C₁₄H₁₂O₃S
canonical SMILES: CC(C1=CC=C(C=C1)C(=O)C2=CC=CS2)C(=O)O
World Health Organisation international non-proprietary name: suprofen
defined daily dose: 0.4
physically interacts with: Prostaglandin-endoperoxide synthase 2
Commons category: Suprofen

Sources (3)

via Wikidata · CC0

Article · Italiano

Suprofene (nella fase sperimentale conosciuto anche con la sigla R 25 061 e con la sigla TN-762), chimicamente acido alfa-metil-4-(2-tienilcarbonil) benzeneacetico, è una molecola appartenente alla classe dei farmaci antinfiammatori non steroidei (FANS). Il farmaco, sintetizzato dalla società farmaceutica Janssen, è dotato di proprietà di tipo antinfiammatorio, analgesico, antipiretico e di antiaggregazione piastrinica.In seguito a numerose segnalazioni di effetti nefrotossici con evoluzione verso l'insufficienza renale acuta, suprofene è stato sospeso dalla commercializzazione in tutto il mondo.

Abstract from DBpedia / Wikipedia · CC BY-SA