Also known as ERV29, surfeit 4
Surfeit locus protein 4 or Surf4 is a protein involved in regulating export of some proteins from the endoplasmic reticulum to the golgi bodies. Surf4 is involved in trafficking soluble (i.e. non-membrane-bound) proteins, namely lipoproteins and PCSK9. It recognizes cargo proteins via a three-amino-acid sequence near the N-termini. The related protein in yeast is called Erv29p.
This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
via MyGene.info
Surfeit locus protein 4 or Surf4 is a protein involved in regulating export of some proteins from the endoplasmic reticulum to the golgi bodies. Surf4 is involved in trafficking soluble (i.e. non-membrane-bound) proteins, namely lipoproteins and PCSK9. It recognizes cargo proteins via a three-amino-acid sequence near the N-termini. The related protein in yeast is called Erv29p.
This gene is named based on its location in the surfeit gene cluster, composed of six housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. Surf4's yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).