SURF4
Sign in to saveAlso known as ERV29, surfeit 4
Surfeit locus protein 4 or Surf4 is a protein involved in regulating export of some proteins from the endoplasmic reticulum to the golgi bodies. Surf4 is involved in trafficking soluble (i.e. non-membrane-bound) proteins, namely lipoproteins and PCSK9. It recognizes cargo proteins via a three-amino-acid sequence near the N-termini. The related protein in yeast is called Erv29p.
In the Vinony graph
Within Vinony's link graph, SURF4 is referenced by 2 other articles, and connects out to PubMed, human chromosome 9 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 9.
Its subject is documented across 5 Wikipedia language editions.
Gene data
SURF4- Name
- surfeit 4
- Type
- protein-coding
- Position
- 133,361,450–133,376,233 (−)
- Aliases
- ERV29
- Ensembl
- ENSG00000280951
- RefSeq RNA
- NM_001280788.2, NM_001280789.2, NM_001280790.2, NM_001280791.2, NM_001280792.2
- RefSeq protein
- NP_001267717.1, NP_001267718.1, NP_001267719.1, NP_001267720.1, NP_001267721.1
This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
surfeit 4
- Symbol
- SURF4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:133,361,450-133,376,233
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 6052
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6836
- chromosome
- human chromosome 9
- genomic start
- 133361450
- genomic end
- 136242970
- cytogenetic location
- 9q34.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Surfeit locus protein 4 or Surf4 is a protein involved in regulating export of some proteins from the endoplasmic reticulum to the golgi bodies. Surf4 is involved in trafficking soluble (i.e. non-membrane-bound) proteins, namely lipoproteins and PCSK9. It recognizes cargo proteins via a three-amino-acid sequence near the N-termini. The related protein in yeast is called Erv29p.
This gene is named based on its location in the surfeit gene cluster, composed of six housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. Surf4's yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles.
Excerpted from Wikipedia’s “SURF4” article, available under the CC BY-SA 4.0 licence.