File:Thalidomide_enantiomers.svg · Wikimedia Commons · See Wikimedia Commons
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Sign in to saveAlso known as K-17, 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline, N-(2,6-dioxo-3-piperidyl)phthalimide, (±)-thalidomide, 3-Phthalimidoglutarimide, N-Phthalyl-glutaminsaeure-imid, Talidomida, Thalidomidum
Thalidomide, sold under the brand names Contergan, Distaval and Thalomid among others, is an oral administered medication used to treat a number of cancers (e.g., multiple myeloma), graft-versus-host disease, and many skin disorders (e.g., complications of leprosy such as skin lesions). Thalidomide has been used to treat conditions associated with HIV: aphthous ulcers, HIV-associated wasting syndrome, diarrhea, and Kaposi's sarcoma, but increases in HIV viral load have been reported.
Thalidomide is a medication taken by mouth that is used today to treat various cancers, graft-versus-host disease, skin conditions, and certain HIV-related problems. It matters because it is an effective treatment option for several serious medical conditions, though it has been associated with some complications in certain uses, such as increases in HIV viral load in some patients.
AI-generated from the Wikipedia summary — may contain errors.
Key facts
- Drug.Watchedfields
- changed
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 420478187
- Drug.image
- Thalidomide enantiomers.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.chirality
- Racemic mixture
- Drug.tradename
- Contergan, Thalomid, others
- Drug.MedlinePlus
- a699032
- Drug.licence_EU
- yes
- Drug.DailyMedID
- Thalidomide
- Drug.licence_US
- Thalidomide
- Drug.pregnancy_AU
- X
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- L04
- Drug.ATC_suffix
- AX02
- Drug.legal_AU
- S4
- Drug.legal_BR
- C3
via Wikipedia infobox
Chemical data
- Formula
- C13H10N2O4
- Molecular weight
- 258.23 g/mol
- IUPAC name
- 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
- SMILES
- C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
- InChIKey
- UEJJHQNACJXSKW-UHFFFAOYSA-N
- XLogP
- 0.3
- Polar surface area
- 83.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
- Mass
- 258.064057
- Has use
- medication
Show 11 more facts
- Commons category
- Thalidomide
- chemical formula
- C₁₃H₁₀N₂O₄
- medical condition treated
- multiple myeloma
- World Health Organisation international non-proprietary name
- thalidomide
- canonical SMILES
- C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
- defined daily dose
- 0.1
- MCN code
- 2925.19.10
- native label
- Thalidomide
- route of administration
- oral administration
- has effect
- Phocomelia due to thalidomide
- physically interacts with
- Cereblon
Sources (12)
via Wikidata · CC0