thromboxane a2

Also known as TXA2, 9S,11S-epoxy,15S-hydroxy-thromboxa-5Z,13E-dien-1-oic acid, TXA-2, (1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-Heptenoate, (5Z,13E)-(15S)-9a,11a-epoxy-15-Hydroxythromboxa-5,13-dienoic acid, (5Z,13E)-(15S)-9a,11a-epoxy-15-Hydroxythromboxa-5,13-dienoate, (1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-Heptenoic acid, RCS

chemical compound

Chemical data

Formula: C20H32O5
Molecular weight: 352.5 g/mol
IUPAC name: (Z)-7-[(1S,3R,4S,5S)-3-[(E,3S)-3-hydroxyoct-1-enyl]-2,6-dioxabicyclo[3.1.1]heptan-4-yl]hept-5-enoic acid
SMILES: CCCCC[C@@H](/C=C/[C@@H]1[C@H]([C@@H]2C[C@@H](O2)O1)C/C=C\CCCC(=O)O)O
InChIKey: DSNBHJFQCNUKMA-SCKDECHMSA-N
XLogP: 3.4
Polar surface area: 76 Å²
H-bond donors: 2
H-bond acceptors: 5
Formal charge: 0

via PubChem

Research

11,658 papers

Thromboxane A2 receptors.Journal of lipid mediators and cell signalling · 1995
Thromboxane A2 receptor antagonists.Medicinal research reviews · 1991
Thromboxane a2: biosynthesis and effects on platelets.Advances in prostaglandin, thromboxane, and leukotriene research · 1982
Interactions between thromboxane A₂, thromboxane/prostaglandin (TP) receptors, and endothelium-derived hyperpolarization.Cardiovascular research · 2014
Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology.Pharmacology & therapeutics · 2008

via PubMed

Wikidata facts

Subclass of: thromboxane
Mass: 352.224974

Show 5 more facts

chemical formula: C₂₀H₃₂O₅
found in taxon: Hypericum perforatum
canonical SMILES: CCCCCC(C=CC1C(C2CC(O2)O1)CC=CCCCC(=O)O)O
isomeric SMILES: CCCCC[C@@H](/C=C/[C@@H]1[C@H]([C@@H]2C[C@@H](O2)O1)C/C=C\CCCC(=O)O)O
subject has role: primary metabolite

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