TOM1

Also known as target of myb1 membrane trafficking protein, IMD85

Target of Myb protein 1 is a protein that in humans is encoded by the TOM1 gene.

Gene data

TOM1

Name: target of myb1 membrane trafficking protein
Type: protein-coding
Position: 35,299,275–35,347,995 (+)
Aliases: IMD85
Ensembl: ENSG00000100284
RefSeq RNA: NM_001135729.2, NM_001135730.2, NM_001135732.2, NM_005488.3, NR_024194.2
RefSeq protein: NP_001129201.1, NP_001129202.1, NP_001129204.1, NP_005479.1, XP_011528120.1

This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].

Pathways

Innate Immune System Immune System Neutrophil degranulation

via MyGene.info

Gene · Ensembl

target of myb1 membrane trafficking protein

Symbol: TOM1
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:35,299,275-35,351,740
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein TOM1 PDB 1elk.png

Show 6 more facts

HomoloGene ID: 88453
exact match: identifiers.org/ncbigene/10043
genomic end: 35347992
genomic start: 35695268
cytogenetic location: 22q12.3
Commons category: TOM1

Sources (4)

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Contents

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Target of Myb protein 1 is a protein that in humans is encoded by the TOM1 gene.

The specific function of this gene has not yet been determined, yet it may involve the translocation of growth factor receptor complexes to the lysosome for degradation. This gene is localized to 22q13.1, with HMOX1 and MCM5 distally and HMG2L1 proximally positioned.