TOM1

Also known as target of myb1 membrane trafficking protein, IMD85

Target of Myb protein 1 is a protein that in humans is encoded by the TOM1 gene.

Gene data

TOM1

Name: target of myb1 membrane trafficking protein
Type: protein-coding
Position: 35,299,275–35,347,995 (+)
Aliases: IMD85
Ensembl: ENSG00000100284
RefSeq RNA: NM_001135729.2, NM_001135730.2, NM_001135732.2, NM_005488.3, NR_024194.2
RefSeq protein: NP_001129201.1, NP_001129202.1, NP_001129204.1, NP_005479.1, XP_011528120.1

This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].

Gene Ontology

Biological process

endocytosis signal transduction

Article

4 sections

Contents

Interactions
References
Further reading
External links

Target of Myb protein 1 is a protein that in humans is encoded by the TOM1 gene.

The specific function of this gene has not yet been determined, yet it may involve the translocation of growth factor receptor complexes to the lysosome for degradation. This gene is localized to 22q13.1, with HMOX1 and MCM5 distally and HMG2L1 proximally positioned.