trimeperidine

Also known as Promedol

Trimeperidine (trade name Promedol) is an opioid analgesic that is an analogue of prodine. It was developed in the early 1950s in the USSR during research into the related drug pethidine.

Research

275 papers

[Efficiency and safety of a fixed combination of Orphenadrine and Diclofenac for postoperative analgesia in cardiac surgery patients].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2022
[Ketoprophen and nefopam combination for postoperative analgesia with minimal use of narcotic analgesics in cardio-surgical patients].Anesteziologiia i reanimatologiia · 2013
[Analgesia in hemophiliac patients during orthopedic surgery].Terapevticheskii arkhiv · 2014
Changes in Respiratory Function during Treatment with Combination of Analgesic Substances Trimeperidine and Dexmedetomidine.Bulletin of experimental biology and medicine · 2016
[The use of central acting analgesic nefopam in postoperative analgesia in cardiac surgery patients].Anesteziologiia i reanimatologiia · 2013

via PubMed

Wikidata facts

Mass: 275.18852904

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chemical formula: C₁₇H₂₅NO₂
canonical SMILES: CCC(=O)OC1(CC(N(CC1C)C)C)C2=CC=CC=C2
Commons category: Trimeperidine
MCN code: 2933.33.93
isomeric SMILES: CCC(=O)OC1(C[C@@H](N(C[C@H]1C)C)C)C2=CC=CC=C2

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References

Trimeperidine (trade name Promedol) is an opioid analgesic that is an analogue of prodine. It was developed in the early 1950s in the USSR during research into the related drug pethidine.

Trimeperidine has four structural isomers, of which two are active, the γ isomer trimeperidine, and the β isomer isopromedol. It is around half the potency of morphine as an analgesic, and has been widely used for the treatment of pain.