APBB1
Sign in to saveAlso known as amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65), FE65, MGC:9072, RIR, amyloid beta precursor protein binding family B member 1
Amyloid beta A4 precursor protein-binding family B member 1 is a protein that in humans is encoded by the APBB1 gene.
Gene data
APBB1- Name
- amyloid beta precursor protein binding family B member 1
- Type
- protein-coding
- Aliases
- FE65, MGC:9072, RIR
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012].
via MyGene.info
Gene · Ensembl
amyloid beta precursor protein binding family B member 1
- Symbol
- APBB1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:6,395,111-6,419,515
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein APBB1 PDB 2e45.png
Show 5 more facts
- HomoloGene ID
- 898
- exact match
- identifiers.org/ncbigene/322
- genomic start
- 6395125
- genomic end
- 6440644
- cytogenetic location
- 11p15.4
Sources (3)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Interactions
- References
- External links
- Further reading
Amyloid beta A4 precursor protein-binding family B member 1 is a protein that in humans is encoded by the APBB1 gene.
== Function ==