AP1B1

Also known as ADTB1, AP105A, BAM22, CLAPB2, adaptor related protein complex 1 beta 1 subunit, adaptor related protein complex 1 subunit beta 1, KIDAR

AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene.

Gene data

AP1B1

Name: adaptor related protein complex 1 subunit beta 1
Type: protein-coding
Position: 29,327,680–29,388,612 (−)
Aliases: ADTB1, AP105A, BAM22, CLAPB2, KIDAR
Ensembl: ENSG00000100280
RefSeq RNA: NM_001127.4, NM_001166019.2, NM_001378562.1, NM_001378563.1, NM_001378564.1
RefSeq protein: NP_001118.3, NP_001159491.1, NP_001365491.1, NP_001365492.1, NP_001365493.1

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

Pathways

Lysosome - Homo sapiens (human)Human immunodeficiency virus 1 infection - Homo sapiens (human)Adaptive Immune System HIV Infection Host Interactions of HIV factors Disease Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Nef mediated downregulation of MHC class I complex cell surface expression The role of Nef in HIV-1 replication and disease pathogenesis Immune System

via MyGene.info

Gene · Ensembl

adaptor related protein complex 1 subunit beta 1

Symbol: AP1B1
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:29,327,680-29,388,612
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: AP-1 complex subunit beta-1 within the AP1 clathrin adaptor core 1W63.png

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HomoloGene ID: 21972
exact match: identifiers.org/ncbigene/162
genomic end: 29819168
genomic start: 29723669
cytogenetic location: 22q12.2

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AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene.

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Two transcript variants encoding different isoforms have been found for this gene, and variants utilizing alternative polyadenylation signals exist.