AP3M1

Also known as adaptor related protein complex 3 mu 1 subunit, adaptor related protein complex 3 subunit mu 1

AP-3 complex subunit mu-1 is a protein that in humans is encoded by the AP3M1 gene.

In the Vinony graph

Within Vinony's link graph, AP3M1 is referenced by 83 other articles, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 10.

Its subject is documented across 6 Wikipedia language editions.

Gene data

AP3M1

Name: adaptor related protein complex 3 subunit mu 1
Type: protein-coding
Position: 74,120,118–74,151,055 (−)
Ensembl: ENSG00000185009
RefSeq RNA: NM_001320263.2, NM_001320264.2, NM_001320265.2, NM_012095.6, NM_207012.4
RefSeq protein: NP_001307192.1, NP_001307193.1, NP_001307194.1, NP_036227.1, NP_996895.1

The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane, and it may directly function in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2016].

Pathways

Lysosome - Homo sapiens (human)Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis Protein folding Metabolism of proteins

via MyGene.info

Gene · Ensembl

adaptor related protein complex 3 subunit mu 1

Symbol: AP3M1
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:74,120,118-74,151,055
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 22693
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/26985
genomic end: 74150842
genomic start: 75881524
chromosome: human chromosome 10
cytogenetic location: 10q22.2
expressed in: appendix

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
External links
Further reading

AP-3 complex subunit mu-1 is a protein that in humans is encoded by the AP3M1 gene.

The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane and may be directly involved in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternatively spliced transcript variants encoding the same protein have been observed.

Excerpted from Wikipedia’s “AP3M1” article, available under the CC BY-SA 4.0 licence.