Structure via PubChem · Public domain (PubChem)
bufexamac
Sign in to saveAlso known as CP-1044-J3, Paraderm®, Parfenac®, 4-Butoxy-N-hydroxybenzeneacetamide, 4-Butoxyphenylacetohydroxamic acid
Bufexamac is a drug used as an anti-inflammatory agent on the skin, as well as rectally. Common brand names include Paraderm and Parfenac. It was withdrawn in Europe and Australia because of allergic reactions.
Key facts
- Drug.H
- 17
- Drug.N
- 1
- Drug.O
- 3
- Drug.IUPAC_name
- 2-(4-butoxyphenyl)-N-hydroxyacetamide
- Drug.image
- Bufexamac Structural Formula V2.svg
- Drug.image_class
- skin-invert-image
- Drug.legal_status
- OTC
- Drug.routes_of_administration
- Topical, rectal
- Drug.excretion
- Renal
- Drug.IUPHAR_ligand
- 7498
- Drug.CAS_number
- 2438-72-4
- Drug.ATC_prefix
- M01
- Drug.ATC_suffix
- AB17
- Drug.PubChem
- 2466
- Drug.ChEMBL
- 94394
- Drug.ChemSpiderID
- 2372
- Drug.UNII
- 4T3C38J78L
- Drug.KEGG
- D01271
via Wikipedia infobox
Chemical data
- Formula
- C12H17NO3
- Molecular weight
- 223.27 g/mol
- IUPAC name
- 2-(4-butoxyphenyl)-N-hydroxyacetamide
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- rheumatic disease, Myalgia, Arthralgia
via ChEMBL · EBI
Research
155 papers- Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H.Scientific reports · 2016
- Effects of Bufexamac, a class IIb HDAC inhibitor, on behavior and neuropathological features in an Aβ-induced rat model of Alzheimer's disease.Experimental gerontology · 2025
- [Bufexamac-induced pigmented purpuric eruption].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2009
- In vitro photobiochemical characterization of sulfobutylether-β-cyclodextrin formulation of bufexamac.Journal of pharmaceutical and biomedical analysis · 2011
- Bufexamac and diclofenac: frequency of contact sensitization and absence of cross-reactions.Contact dermatitis · 1998
via PubMed
Wikidata facts
- Mass
- 223.121
Show 3 more facts
- chemical formula
- C₁₂H₁₇NO₃
- canonical SMILES
- CCCCOC1=CC=C(C=C1)CC(=O)NO
- World Health Organisation international non-proprietary name
- bufexamac
Sources (2)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Indications
- Pharmacology
- Side effects
- References
Bufexamac is a drug used as an anti-inflammatory agent on the skin, as well as rectally. Common brand names include Paraderm and Parfenac. It was withdrawn in Europe and Australia because of allergic reactions.
==Indications== Ointments and lotions containing bufexamac are used for the treatment of subacute and chronic eczema of the skin, including atopic eczema, as well as sunburn and other minor burns, and itching. Suppositories containing bufexamac in combination with local anaesthetics are used against haemorrhoids.