bufuralol
Sign in to saveAlso known as Bufuralolum
Bufuralol is a potent beta-adrenoceptor antagonist with partial agonist activity. It is metabolized by CYP2D6.
Research
446 papers- Stereoselectivity in the oxidation of bufuralol, a chiral substrate, by human cytochrome P450s.Chirality · 2003
- (+)-bufuralol 1'-hydroxylation activity in human and rhesus monkey intestine and liver.Biochemical pharmacology · 1995
- Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6.Methods in enzymology · 1991
- Bufuralol 1'-hydroxylase activity of the rat. Strain differences and the effects of inhibitors.Biochemical pharmacology · 1986
- Bufuralol metabolism in human liver: a sensitive probe for the debrisoquine-type polymorphism of drug oxidation.European journal of clinical investigation · 1984
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Wikidata facts
- Mass
- 261.173
Show 2 more facts
- chemical formula
- C₁₆H₂₃NO₂
- canonical SMILES
- CCC1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O
Sources (2)
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Article
1 sectionsContents
- References
Bufuralol is a potent beta-adrenoceptor antagonist with partial agonist activity. It is metabolized by CYP2D6.
Most beta blockers are aryloxypropanolamine-based. In this rare exception, the benzofuran oxygen is part of a ring rather than derived from the epichlorohydrin precursor.
Connections
beta blocker
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medication
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circulatory system
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digital object identifier
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chemical formula
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molar mass
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Q180686
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CAS Registry Number
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Q229883
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PubChem
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simplified molecular input line entry specification
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Q2311683
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International Chemical Identifier
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European Chemicals Agency
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epichlorohydrin
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standard state
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Jmol
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Unique Ingredient Identifier
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ChEMBL
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cytochrome P450 family 2 subfamily D member 6
Protein