Structure via PubChem · Public domain (PubChem)
بوفورالول
Sign in to saveAlso known as Bufuralolum, Bufuralol
Bufuralol is a potent beta-adrenoceptor antagonist with partial agonist activity. It is metabolized by CYP2D6.
In the Vinony graph
Vinony's link graph records 560 inbound references to بوفورالول, and connects out to beta blocker, medication and circulatory system.
It sits within the topics Benzofuranethanamines, Beta blockers and Chembox image size set.
Vinony links it to 6 Wikipedia language editions.
Chemical data
- Formula
- C16H23NO2
- Molecular weight
- 261.36 g/mol
- IUPAC name
- 2-(tert-butylamino)-1-(7-ethyl-1-benzofuran-2-yl)ethanol
- SMILES
- CCC1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O
- InChIKey
- SSEBTPPFLLCUMN-UHFFFAOYSA-N
- XLogP
- 3.5
- Polar surface area
- 45.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
446 papers- Stereoselectivity in the oxidation of bufuralol, a chiral substrate, by human cytochrome P450s.Chirality · 2003
- (+)-bufuralol 1'-hydroxylation activity in human and rhesus monkey intestine and liver.Biochemical pharmacology · 1995
- Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6.Methods in enzymology · 1991
- Bufuralol 1'-hydroxylase activity of the rat. Strain differences and the effects of inhibitors.Biochemical pharmacology · 1986
- Bufuralol metabolism in human liver: a sensitive probe for the debrisoquine-type polymorphism of drug oxidation.European journal of clinical investigation · 1984
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 261.173
Show 3 more facts
- chemical formula
- C₁₆H₂₃NO₂
- canonical SMILES
- CCC1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O
- subject has role
- beta blocker
Sources (2)
via Wikidata · CC0
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European Chemicals Agency
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epichlorohydrin
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standard state
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Unique Ingredient Identifier
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ChEMBL
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cytochrome P450 family 2 subfamily D member 6
Protein