Also known as Caco 2, CACO2, Caco-2/ATCC, Caco-II
thumb|0x0px|Phase contrast [[micrograph of confluent Caco-2 cells]] Caco-2 (from Cancer coli, "colon cancer") is an immortalized cell line of human colorectal adenocarcinoma cells. It is primarily used as a model of the intestinal epithelial barrier. In culture, Caco-2 cells spontaneously differentiate into a heterogeneous mixture of intestinal epithelial cells. It was developed in 1977 by Jorgen Fogh at the Sloan-Kettering Institute for Cancer Research.
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thumb|0x0px|Phase contrast [[micrograph of confluent Caco-2 cells]] Caco-2 (from Cancer coli, "colon cancer") is an immortalized cell line of human colorectal adenocarcinoma cells. It is primarily used as a model of the intestinal epithelial barrier. In culture, Caco-2 cells spontaneously differentiate into a heterogeneous mixture of intestinal epithelial cells. It was developed in 1977 by Jorgen Fogh at the Sloan-Kettering Institute for Cancer Research.
==History== The line was developed in 1977 by Jorgen Fogh at the Sloan-Kettering Institute for Cancer Research. The research application of Caco-2 cells was developed during the 1980s by Alain Zweibaum group at INSERM, France as well as Ismael Hidalgo, at the Borchardt laboratory, University of Kansas and Thomas J Raub and at the Upjohn Company. The first publication of the discovery of the spontaneous enterocyte like differentiation was published by Alain Zweibaum group in 1983.
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).