Caco-2
Sign in to saveAlso known as Caco 2, CACO2, Caco-2/ATCC, Caco-II
thumb|0x0px|Phase contrast [[micrograph of confluent Caco-2 cells]] Caco-2 (from Cancer coli, "colon cancer") is an immortalized cell line of human colorectal adenocarcinoma cells. It is primarily used as a model of the intestinal epithelial barrier. In culture, Caco-2 cells spontaneously differentiate into a heterogeneous mixture of intestinal epithelial cells. It was developed in 1977 by Jorgen Fogh at the Sloan-Kettering Institute for Cancer Research.
In the Vinony graph
Within Vinony's link graph, Caco-2 is referenced by 28 other articles, and connects out to enterocyte, International Standard Book Number and enzyme.
It is catalogued under topics including Adenocarcinoma cell lines, Cancer cell lines and Colorectal cancer.
Its subject is documented across 7 Wikipedia language editions.
Research
27,665 papers- Caco-2 Cell Line Standardization with Pharmaceutical Requirements and In Vitro Model Suitability for Permeability Assays.Pharmaceutics · 2023
- The Caco-2 Model: Modifications and enhancements to improve efficiency and predictive performance.International journal of pharmaceutics · 2022
- Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers.Nature protocols · 2007
- Modulation of proliferation, apoptosis and inflammation of Caco-2 epithelial cells and THP-1 macrophage-like monocytes in LPS stimulated co-culture model.Bratislavske lekarske listy · 2021
- Caco-2 monolayers in experimental and theoretical predictions of drug transport.Advanced drug delivery reviews · 2001
via PubMed
Wikidata facts
- Image
- CaCo-2 cells after 21 days in culture.tif
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- Commons category
- Caco-2 cells
- exact match
- purl.obolibrary.org/obo/CLO_0050627
- derived from organism type
- Homo sapiens
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Encyclopedic overview
7 sectionsContents
- History
- Characteristics
- Research applications
- See also
- References
- Further reading
- External links
thumb|0x0px|Phase contrast [[micrograph of confluent Caco-2 cells]] Caco-2 (from Cancer coli, "colon cancer") is an immortalized cell line of human colorectal adenocarcinoma cells. It is primarily used as a model of the intestinal epithelial barrier. In culture, Caco-2 cells spontaneously differentiate into a heterogeneous mixture of intestinal epithelial cells. It was developed in 1977 by Jorgen Fogh at the Sloan-Kettering Institute for Cancer Research.
==History== The line was developed in 1977 by Jorgen Fogh at the Sloan-Kettering Institute for Cancer Research. The research application of Caco-2 cells was developed during the 1980s by Alain Zweibaum group at INSERM, France as well as Ismael Hidalgo, at the Borchardt laboratory, University of Kansas and Thomas J Raub and at the Upjohn Company. The first publication of the discovery of the spontaneous enterocyte like differentiation was published by Alain Zweibaum group in 1983.
Excerpted from Wikipedia’s “Caco-2” article, available under the CC BY-SA 4.0 licence.