カルモフール

Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil, being a lipophilic-masked analog of 5-FU that can be administered orally.

In the Vinony graph

Within Vinony's link graph, カルモフール is referenced by 277 other articles, and connects out to tiazofurin, COVID-19 and mouth.

It sits within the topics Drugboxes which contain changes to verified fields, Drugs with no legal status and ECHA InfoCard ID from Wikidata.

Its subject is documented across 6 Wikipedia language editions.

Chemical data

Formula: C11H16FN3O3
Molecular weight: 257.26 g/mol
IUPAC name: 5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide
SMILES: CCCCCCNC(=O)N1C=C(C(=O)NC1=O)F
InChIKey: AOCCBINRVIKJHY-UHFFFAOYSA-N
XLogP: 2.6
Polar surface area: 78.5 Å²
H-bond donors: 2
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: neoplasm

via ChEMBL · EBI

Research

299 papers

Versatile use of Carmofur: A comprehensive review of its chemistry and pharmacology.Drug development research · 2022
Carmofur Exhibits Antimicrobial Activity Against Streptococcus pneumoniae.Antibiotics (Basel, Switzerland) · 2025
Carmofur prevents cell cycle progression by reducing E2F8 transcription in temozolomide-resistant glioblastoma cells.Cell death discovery · 2023
Temperature/pH-responsive carmofur-loaded nanogels rapidly prepared via one-pot laser-induced emulsion polymerization.Colloids and surfaces. B, Biointerfaces · 2022
Structural basis of main proteases of MERS-CoV bound to antineoplastic drug carmofur.Biochemical and biophysical research communications · 2024

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 257.118
Has use: medication

Show 3 more facts

chemical formula: C₁₁H₁₆FN₃O₃
canonical SMILES: CCCCCCNC(=O)N1C=C(C(=O)NC1=O)F
subject has role: antineoplastic

Sources (2)

via Wikidata · CC0

Article · 日本語

カルモフール（Carmofur）またはHCFU（1-hexylcarbamoyl-5-fluorouracil）は、嘗て販売されていた抗悪性腫瘍薬として使用されるピリミジンアナログである。フルオロウラシル(5-FU)の誘導体であり、経口投与可能な脂溶性5-FUプロドラッグである。日本では2009年3月に販売が終了した。

Abstract from DBpedia / Wikipedia · CC BY-SA