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Structure via PubChem · Public domain (PubChem)
chlormerodrin
Sign in to saveAlso known as 1-[3-(Chloromercuri)-2-methoxypropyl]urea, Chlormerodrine, Chlormerodrinum, Chlormerodrina, {3-[(aminocarbonyl)amino]-2-methoxypropyl}chloromercury, Mercloran, Neohydrin
Chlormerodrin is a mercurial diuretic commercially traded from 1952 until 1974 that was once used to treat patients with heart failure, but is no longer in widespread use. The radiolabelled form (197Hg & 203Hg) had also been used for medical imaging of the kidney and brain and the 197Hg form was even considered a contender for 99mTc by some physicians, but was ultimately discontinued by the FDA in 1989.
In the Vinony graph
Vinony's link graph records 76 inbound references to chlormerodrin, and connects out to collecting duct system, medication and ethanol.
Vinony files it under Chemical pages without ChemSpiderID, Drugs not assigned an ATC code and Drugs with no legal status.
Vinony links it to 6 Wikipedia language editions.
Chemical data
- Formula
- C5H11ClHgN2O2
- Molecular weight
- 367.2 g/mol
- IUPAC name
- [3-(carbamoylamino)-2-methoxypropyl]-chloromercury
- SMILES
- COC(CNC(=O)N)C[Hg]Cl
- InChIKey
- BJFGVYCULWBXKF-UHFFFAOYSA-M
- Polar surface area
- 64.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- parenteral
via ChEMBL · EBI
Research
642 papers- 197Hg-chlormerodrin dosimetry.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 1968
- Antimicrobial activity of chlormerodrin.Journal of pharmaceutical sciences · 1979
- METABOLISM OF CHLORMERODRIN-HG203.Investigative urology · 1963
- The deposition of Hg203-chlormerodrin in experimental brain tumors.Journal of neurosurgery · 1971
- The distribution of chlormerodrin (neohydrin) in tissues of the rat and dog.The Journal of clinical investigation · 1956
via PubMed
Wikidata facts
- Has part
- carbon
- Mass
- 368.021548
- Has use
- medication
Show 5 more facts
- chemical formula
- C₅H₁₁ClHgN₂O₂
- canonical SMILES
- COC(CNC(=O)N)C[Hg]Cl
- World Health Organisation international non-proprietary name
- chlormerodrin
- has characteristic
- bitterness
- Commons category
- Chlormerodrin
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Chlormerodrin is a mercurial diuretic commercially traded from 1952 until 1974 that was once used to treat patients with heart failure, but is no longer in widespread use. The radiolabelled form (197Hg & 203Hg) had also been used for medical imaging of the kidney and brain and the 197Hg form was even considered a contender for 99mTc by some physicians, but was ultimately discontinued by the FDA in 1989.
== References ==
Excerpted from Wikipedia’s “chlormerodrin” article, available under the CC BY-SA 4.0 licence.