Structure via PubChem · Public domain (PubChem)
ciproxifan
Sign in to saveAlso known as FUB-359, FUB359
Ciproxifan is an extremely potent histamine H3 inverse agonist/antagonist.
Chemical data
- Formula
- C16H18N2O2
- Molecular weight
- 270.33 g/mol
- IUPAC name
- cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone
- SMILES
- C1CC1C(=O)C2=CC=C(C=C2)OCCCC3=CN=CN3
- InChIKey
- ACQBHJXEAYTHCY-UHFFFAOYSA-N
- XLogP
- 2.5
- Polar surface area
- 55 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
140 papers- Dose-related effects of ciproxifan on brain tissue in rats with cerebral ischemia-reperfusion.The International journal of neuroscience · 2024
- Ciproxifan in preventing inhalational anesthetic-induced neurotoxicity!Saudi journal of anaesthesia · 2018
- Ciproxifan attenuates the memory impairment induced by lipopolysaccharide through modulation of cholinergic transmission in the mouse brain.European review for medical and pharmacological sciences · 2022
- Ciproxifan, a histamine H(3) receptor antagonist, reversibly inhibits monoamine oxidase A and B.Scientific reports · 2017
- Procognitive impact of ciproxifan (a histaminergic H(3) receptor antagonist) on contextual memory retrieval after acute stress.CNS neuroscience & therapeutics · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 270.136828
Show 5 more facts
- chemical formula
- C₁₆H₁₈N₂O₂
- canonical SMILES
- C1CC1C(=O)C2=CC=C(C=C2)OCCCC3=CN=CN3
- subject has role
- nootropic
- physically interacts with
- Histamine receptor H4
- Commons category
- Ciproxifan
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Ciproxifan is an extremely potent histamine H3 inverse agonist/antagonist.
The histamine H3 receptor is an inhibitory autoreceptor located on histaminergic nerve terminals, and is believed to be involved in modulating the release of histamine in the brain. Histamine has an excitatory effect in the brain via H1 receptors in the cerebral cortex, and so drugs such as ciproxifan which block the H3 receptor and consequently allow more histamine to be released have an alertness-promoting effect.
Excerpted from Wikipedia’s “ciproxifan” article, available under the CC BY-SA 4.0 licence.