CLDN19
Sign in to saveAlso known as HOMG5, claudin 19
Claudin-19 is a protein that in humans is encoded by the CLDN19 gene. It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport.
In the Vinony graph
Vinony's link graph records 6 inbound references to CLDN19, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Vinony links it to 5 Wikipedia language editions.
Gene data
CLDN19- Name
- claudin 19
- Type
- protein-coding
- Aliases
- HOMG5
The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010].
via MyGene.info
Gene · Ensembl
claudin 19
- Symbol
- CLDN19
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:42,733,093-42,740,286
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 17528
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/149461
- genomic end
- 43205925
- genomic start
- 43198764
- chromosome
- human chromosome 1
- cytogenetic location
- 1p34.2
- expressed in
- trachea
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
Claudin-19 is a protein that in humans is encoded by the CLDN19 gene. It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport.
Claudins, such as CLDN19, are transmembrane proteins found at tight junctions. Tight junctions form barriers that control the passage of ions and molecules across an epithelial sheet and the movement of proteins and lipids between apical and basolateral domains of epithelial cells (Lee et al., 2006).[supplied by OMIM]
Excerpted from Wikipedia’s “CLDN19” article, available under the CC BY-SA 4.0 licence.