Complement C5a receptor 1
Sign in to saveAlso known as C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin receptor, C5a-R, C5aR, C5a anaphylatoxin chemotactic receptor, C5AR1, C5a ligand, complement component 5a receptor 1
mammalian protein found in Homo sapiens
Protein · UniProt
C5a anaphylatoxin chemotactic receptor 1
- Gene
- C5AR1
- Organism
- Homo sapiens (Human)
- Length
- 350 aa
- Molecular mass
- 39,336 Da
- Evidence
- 1: Evidence at protein level
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:36806352, PubMed:7622471, PubMed:8182049, PubMed:9553099). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:36806352, PubMed:37852260). C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
3 registered- PHASE1COMPLETEDA Study of Safety and Drug Levels of HIB210 in Healthy VolunteersHI-Bio, A Biogen Company · NCT05928585
- PHASE1COMPLETEDA Study to Evaluate the Pharmacokinetics of Avacopan (CCX168) in Participants With Mild or Moderate Hepatic ImpairmentAmgen · NCT06004934
- PHASE1COMPLETEDA Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Potential of CCX168 With Concomitant MedicationsAmgen · NCT06004947