CUL5

Also known as VACM-1, VACM1, cullin 5, CUL-5

Cullin-5 is a protein that in humans is encoded by the CUL5 gene.

Gene data

CUL5

Name: cullin 5
Type: protein-coding
Position: 108,008,898–108,107,781 (+)
Aliases: CUL-5, VACM-1, VACM1
Ensembl: ENSG00000166266
RefSeq RNA: NM_003478.6, XM_005271682.3, XM_011543013.3, XM_017018363.3, XM_047427640.1
RefSeq protein: NP_003469.2, XP_005271739.1, XP_011541315.1, XP_016873852.1, XP_047283596.1

Enables ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within cerebral cortex radially oriented cell migration and radial glia guided migration of Purkinje cell. Located in site of DNA damage. Part of Cul5-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

Pathways

Ubiquitin mediated proteolysis - Homo sapiens (human)Human immunodeficiency virus 1 infection - Homo sapiens (human)Signaling by ERBB2 Cytokine Signaling in Immune system Cytokine Signaling in Immune system Adaptive Immune System Signal Transduction HIV Infection Host Interactions of HIV factors Disease

via MyGene.info

Gene · Ensembl

cullin 5

Symbol: CUL5
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:108,008,821-108,107,781
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein CUL5 PDB 3DPL.png

Show 5 more facts

HomoloGene ID: 2597
exact match: identifiers.org/ncbigene/8065
genomic end: 108107761
genomic start: 108008898
cytogenetic location: 11q22.3

Sources (4)

via Wikidata · CC0

~1 min read

Article

7 sections

Contents

Discovery
Tissue distribution
Function
Interactions
References
External links
Further reading

Cullin-5 is a protein that in humans is encoded by the CUL5 gene.

==Discovery== The mammalian gene product was originally discovered by expression cloning, due to the protein's ability to mobilize intracellular calcium in response to the peptide hormone arginine vasopressin. It was first titled VACM-1, for vasopressin-activated, calcium-mobilizing receptor. Since then, VACM-1 has been shown to be homologous to the Cullin family of proteins, and was subsequently dubbed cul5.