SOCS2

Also known as CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2, suppressor of cytokine signaling 2

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.

Gene data

SOCS2

Name: suppressor of cytokine signaling 2
Type: protein-coding
Position: 93,569,808–93,583,487 (+)
Aliases: CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
Ensembl: ENSG00000120833
RefSeq RNA: NM_001270467.2, NM_001270468.2, NM_001270469.2, NM_001270470.1, NM_001270471.2
RefSeq protein: NP_001257396.1, NP_001257397.1, NP_001257398.1, NP_001257399.1, NP_001257400.1

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].

Gene Ontology

Biological process

regulation of cell growth cell surface receptor signaling pathway via JAK-STAT regulation of signal transduction negative regulation of signal transduction protein ubiquitination cytokine-mediated signaling pathway response to estradiol cellular response to hormone stimulus

Molecular function

cytokine receptor binding growth hormone receptor binding insulin-like growth factor receptor binding protein binding JAK pathway signal transduction adaptor activity phosphorylation-dependent protein binding ubiquitin-like ligase-substrate adaptor activity

Cellular component

cytoplasm cytoplasm cytosol Cul5-RING ubiquitin ligase complex

Pathways

JAK-STAT signaling pathway - Homo sapiens (human)Insulin signaling pathway - Homo sapiens (human)Prolactin signaling pathway - Homo sapiens (human)Type II diabetes mellitus - Homo sapiens (human)Growth hormone synthesis, secretion and action - Homo sapiens (human)Interleukin-7 signaling Cytokine Signaling in Immune system Cytokine Signaling in Immune system Immune System Immune System

via MyGene.info

Gene · Ensembl

suppressor of cytokine signaling 2

Symbol: SOCS2
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:93,569,808-93,586,595
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein SOCS2 PDB 2c9w.png

Show 5 more facts

HomoloGene ID: 2880
exact match: identifiers.org/ncbigene/8835
cytogenetic location: 12q22
genomic end: 93977263
genomic start: 93963590

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Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.