SOCS2

Also known as CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2, suppressor of cytokine signaling 2

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.

Gene data

SOCS2

Name: suppressor of cytokine signaling 2
Type: protein-coding
Position: 93,569,808–93,583,487 (+)
Aliases: CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
Ensembl: ENSG00000120833
RefSeq RNA: NM_001270467.2, NM_001270468.2, NM_001270469.2, NM_001270470.1, NM_001270471.2
RefSeq protein: NP_001257396.1, NP_001257397.1, NP_001257398.1, NP_001257399.1, NP_001257400.1

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].

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Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.