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GeneQ18028003· pop 6· linked from 852 articles

IRF7

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Also known as IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H, IMD39, interferon regulatory factor 7, IRF-7

Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.

Gene data

IRF7

Name: interferon regulatory factor 7
Type: protein-coding
Position: 612,551–615,983 (−)
Aliases: IMD39, IRF-7, IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H
Ensembl: ENSG00000276561
RefSeq RNA: NM_001440440.1, NM_001440442.1, NM_001440444.1, NM_001440445.1, NM_001440446.1
RefSeq protein: NP_001427369.1, NP_001427371.1, NP_001427373.1, NP_001427374.1, NP_001427375.1

This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses. [provided by RefSeq, Jul 2021].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II immune system process cytoplasmic pattern recognition receptor signaling pathway regulation of adaptive immune response regulation of DNA-templated transcription regulation of transcription by RNA polymerase II DNA damage response signal transduction

Molecular function

transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding

Cellular component

chromatin chromatin nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

Toll-like receptor signaling pathway - Homo sapiens (human)NOD-like receptor signaling pathway - Homo sapiens (human)RIG-I-like receptor signaling pathway - Homo sapiens (human)Cytosolic DNA-sensing pathway - Homo sapiens (human)Hepatitis C - Homo sapiens (human)Hepatitis B - Homo sapiens (human)Measles - Homo sapiens (human)Influenza A - Homo sapiens (human)Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)Herpes simplex virus 1 infection - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

interferon regulatory factor 7

Symbol: IRF7
Biotype: Protein coding
Organism: Homo sapiens
Location: Chr HSCHR11_1_CTG8:142,446-145,898
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 6 more facts

HomoloGene ID: 128624
exact match: identifiers.org/ncbigene/3665
genomic start: 612553
genomic end: 615983
cytogenetic location: 11p15.5
Commons category: Interferon regulatory factor-7

Sources (5)

via Wikidata · CC0

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Article

6 sections

Contents

Function
Interactions
See also
References
Further reading
External links

Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.

== Function ==

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Categories

Genes on human chromosome 11 Transcription factors